Ontology highlight
ABSTRACT:
SUBMITTER: Bressan M
PROVIDER: S-EPMC6007983 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Bressan Michael M Henley Trevor T Louie Jonathan D JD Liu Gary G Christodoulou Danos D Bai Xue X Taylor Joan J Seidman Christine E CE Seidman J G JG Mikawa Takashi T
Cell reports 20180501 8
Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular composition of the SAN has been a point of interest for more than a century, the biological processes that drive the tissue-level assembly of the cells within the SAN are unknown. Here, ...[more]