Ontology highlight
ABSTRACT:
SUBMITTER: Doigneaux C
PROVIDER: S-EPMC7363121 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Doigneaux Cyrielle C Pedley Anthony M AM Mistry Ishna N IN Papayova Monika M Benkovic Stephen J SJ Tavassoli Ali A
The Journal of biological chemistry 20200521 28
The purinosome is a dynamic metabolic complex composed of enzymes responsible for <i>de novo</i> purine biosynthesis, whose formation has been associated with elevated purine demand. However, the physiological conditions that govern purinosome formation in cells remain unknown. Here, we report that purinosome formation is up-regulated in cells in response to a low-oxygen microenvironment (hypoxia). We demonstrate that increased purinosome assembly in hypoxic human cells requires the activation o ...[more]