MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle.
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ABSTRACT:
SUBMITTER: Fang L
PROVIDER: S-EPMC6008395 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle.
Fang Lingzhao L Sørensen Peter P Sahana Goutam G Panitz Frank F Su Guosheng G Zhang Shengli S Yu Ying Y Li Bingjie B Ma Li L Liu George G Lund Mogens Sandø MS Thomsen Bo B
Scientific reports 20180619 1
MicroRNAs (miRNA) are key modulators of gene expression and so act as putative fine-tuners of complex phenotypes. Here, we hypothesized that causal variants of complex traits are enriched in miRNAs and miRNA-target networks. First, we conducted a genome-wide association study (GWAS) for seven functional and milk production traits using imputed sequence variants (13~15 million) and >10,000 animals from three dairy cattle breeds, i.e., Holstein (HOL), Nordic red cattle (RDC) and Jersey (JER). Seco ...[more]
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