Ontology highlight
ABSTRACT:
SUBMITTER: Chen YA
PROVIDER: S-EPMC6008406 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Chen Yu-An YA Shih Hua-Wei HW Lin Yi-Chun YC Hsu Hui-Ying HY Wu Tsu-Fang TF Tsai Chen-Han CH Wu Chia-Lin CL Wu Hui-Yu HY Hsieh Jer-Tsong JT Tang Chih-Hsin CH Lai Chih-Ho CH
Frontiers in pharmacology 20180613
Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, are commonly used to treat hypercholesterolemia, exhibiting beneficial effects on cardiovascular diseases and on several types of cancers, including PCa. Howev ...[more]