The transcriptional response to hypoxic insult controlled by FRA-2.
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ABSTRACT:
SUBMITTER: Butler TL
PROVIDER: S-EPMC6009107 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
The transcriptional response to hypoxic insult controlled by FRA-2.
Butler Tanya L TL Pennypacker Keith R KR
Gene expression 20050101 2
FRA-2 is involved in cellular differentiation and is also upregulated in response to ischemic injury to the brain. To shed light on the function of this transcription factor, a novel microarray analysis was utilized to identify FRA-2-dependent gene expression increased in the hypoxic response. Genes were identified that were upregulated by exposure of neuronally differentiated PC12 cells to hypoxia. Using a dominant negative construct to block FRA-2, a second subset of genes that were FRA-2 depe ...[more]
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