Ontology highlight
ABSTRACT:
SUBMITTER: Al Ahmad A
PROVIDER: S-EPMC3049523 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Al Ahmad Abraham A Taboada Carole Bürgi CB Gassmann Max M Ogunshola Omolara O OO
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100908 2
Understanding regulation of blood-brain barrier (BBB) is crucial to reduce/prevent its disruption during injury. As high brain complexity makes interpretation of in vivo data challenging, BBB studies are frequently performed using simplified in vitro models. However, many models fail to address the three-dimensional (3D) cellular interactions that occur in vivo, an important feature that may explain discrepancies in translation of in vitro data to the in vivo situation. We have designed and char ...[more]