Ontology highlight
ABSTRACT:
SUBMITTER: Hung KH
PROVIDER: S-EPMC6009645 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Hung Kuo-Hsuan KH Woo Yong H YH Lin I-Ying IY Liu Chin-Hsiu CH Wang Li-Chieh LC Chen Hsin-Yu HY Chiang Bor-Luen BL Lin Kuo-I KI
Nucleic acids research 20180601 11
T follicular helper (Tfh) cell-derived signals promote activation and proliferation of antigen-primed B cells. It remains unclear whether epigenetic regulation is involved in the B cell responses to Tfh cell-derived signals. Here, we demonstrate that Tfh cell-mimicking signals induce the expression of histone demethylases KDM4A and KDM4C, and the concomitant global down-regulation of their substrates, H3K9me3/me2, in B cells. Depletion of KDM4A and KDM4C potentiates B cell activation and prolife ...[more]