Ontology highlight
ABSTRACT:
SUBMITTER: Becker JR
PROVIDER: S-EPMC6009675 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Becker Jordan R JR Gallo David D Leung Wendy W Croissant Taylor T Thu Yee Mon YM Nguyen Hai Dang HD Starr Timothy K TK Brown Grant W GW Bielinsky Anja-Katrin AK
Nucleic acids research 20180601 11
Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer types and is a marker for poor prognosis. To better understand the cellular consequences of FEN1 overexpression we utilized a model of its Saccharomyces cerevisiae homolog, RAD27. In this system, we discovered that flap endonuclease overexpression impedes replication fork progression and leads to an accumulation of cells in mid-S phase. This was accompanied by increased phosphorylation of the checkpoint kinase ...[more]