Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai S
PROVIDER: S-EPMC549611 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Sakurai Shigeru S Kitano Ken K Yamaguchi Hiroto H Hamada Keisuke K Okada Kengo K Fukuda Kotaro K Uchida Makiyo M Ohtsuka Eiko E Morioka Hiroshi H Hakoshima Toshio T
The EMBO journal 20041216 4
Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its endonuclease activity. The structural basis of the FEN1-PCNA interaction was revealed by the crystal structure of the complex between human FEN1 and PCNA. The main interface involves the C-terminal tail of FEN1, which forms two beta-strands connected by a short helix, the betaA-alphaA-betaB motif, participating in beta-beta and hydr ...[more]