Ontology highlight
ABSTRACT:
SUBMITTER: Granchi C
PROVIDER: S-EPMC6009861 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Granchi Carlotta C Caligiuri Isabella I Bertelli Eleonora E Poli Giulio G Rizzolio Flavio F Macchia Marco M Martinelli Adriano A Minutolo Filippo F Tuccinardi Tiziano T
Journal of enzyme inhibition and medicinal chemistry 20171201 1
Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characterised by an irreversible mechanism of action and this behavior determines an unwanted chronic MAGL inactivation, which acquires a functional antagonism of the endocannabinoid system. The possible use of reversible MAGL inhibitors has only recently been ...[more]