Ontology highlight
ABSTRACT:
SUBMITTER: Poli G
PROVIDER: S-EPMC6352951 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Poli Giulio G Lapillo Margherita M Jha Vibhu V Mouawad Nayla N Caligiuri Isabella I Macchia Marco M Minutolo Filippo F Rizzolio Flavio F Tuccinardi Tiziano T Granchi Carlotta C
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of the side effects associated to prolonged MAGL inactivation, is a hot topic in medicinal chemistry. In this study, a novel phenyl(piperazin-1-yl)methanone inhibitor of MAGL was identified through a virtual screening protocol based on a fingerprint-drive ...[more]