Ontology highlight
ABSTRACT:
SUBMITTER: Altamimi AS
PROVIDER: S-EPMC6009863 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Altamimi Abdul-Malek S AS Alafeefy Ahmed M AM Balode Agnese A Vozny Igor I Pustenko Aleksandrs A El Shikh Mohey Eldin ME Alasmary Fatmah A S FAS Abdel-Gawad Sherif A SA Žalubovskis Raivis R
Journal of enzyme inhibition and medicinal chemistry 20181201 1
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC<sub>50</sub> = 117-174 µM. Seven compounds exhibited better LDHA inhibition (IC<sub>50</sub> 117-136 µM) compared to known LDH inhibitor - galloflavin (IC<sub>50</sub> 157 µM). ...[more]