Ontology highlight
ABSTRACT:
SUBMITTER: Gul HI
PROVIDER: S-EPMC6009867 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Gul Halise Inci HI Yamali Cem C Yesilyurt Fatma F Sakagami Hiroshi H Kucukoglu Kaan K Gulcin Ilhami I Gul Mustafa M Supuran Claudiu T CT
Journal of enzyme inhibition and medicinal chemistry 20171201 1
In this study, 4-[5-(4-hydroxyphenyl)-3-aryl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide derivatives (8-14) were synthesized for the first time by microwave irradiation and their chemical structures were confirmed by <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. Cytotoxic activities and inhibitory effects on carbonic anhydrase I and II isoenzymes of the compounds were investigated. The compounds 9 (PSE = 4.2), 12 (PSE = 4.1) and 13 (PSE = 3.9) with the highest potency selectivity expression ...[more]