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Microwave-Assisted Synthesis of N-Phenylsuccinimide.

ABSTRACT: A microwave-assisted synthesis of N-phenylsuccinimide has been developed for the second-semester organic teaching laboratory. Utilizing this procedure, N-phenylsuccinimide can be synthesized by heating a mixture of aniline and succinic anhydride in a domestic microwave oven for four minutes in moderate yields (40-60%). This technique reduces the reaction time as compared to the traditional synthesis by several hours, which allows the preparation to be achieved in a single organic chemistry laboratory period. This reaction is performed in the absence of solvent, is energy efficient, and is atom economical; therefore, it represents a "greener" preparation than the traditional synthesis of N-phenylsuccinimide.

SUBMITTER: Shell TA

PROVIDER: S-EPMC3224042 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Microwave-Assisted Synthesis of N-Phenylsuccinimide.

Shell Thomas A TA Shell Jennifer R JR Poole Kathleen A KA Guetzloff Thomas F TF

Journal of chemical education 20111001 10

A microwave-assisted synthesis of N-phenylsuccinimide has been developed for the second-semester organic teaching laboratory. Utilizing this procedure, N-phenylsuccinimide can be synthesized by heating a mixture of aniline and succinic anhydride in a domestic microwave oven for four minutes in moderate yields (40-60%). This technique reduces the reaction time as compared to the traditional synthesis by several hours, which allows the preparation to be achieved in a single organic chemistry labor ...[more]

PMID: 22125340

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