Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC6010910 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chen Ying-Ling YL Li Dong-Ping DP Jiang Hong-Yue HY Yang Yang Y Xu Li-Li LL Zhang Shun-Cai SC Gao Hong H
Cancer medicine 20180419 6
HACE1 E3 ligase was discovered to be down-regulated in several cancers while its role in regulating tumors was merely understood. This study aimed to explore the specific effect of HACE1 played in gastric tumorigenesis and its potential mechanism. HACE1's expression was found significantly lower in gastric cancer tissues compared with the adjacent normal tissues (P < 0.001). Its protein level in gastric cancer negatively correlated to tumor pathological differentiation (P = 0.019). And in gastri ...[more]