Ontology highlight
ABSTRACT:
SUBMITTER: Siempos II
PROVIDER: S-EPMC6012515 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Siempos Ilias I II Ma Kevin C KC Imamura Mitsuru M Baron Rebecca M RM Fredenburgh Laura E LE Huh Jin-Won JW Moon Jong-Seok JS Finkelsztein Eli J EJ Jones Daniel S DS Lizardi Michael Torres MT Schenck Edward J EJ Ryter Stefan W SW Nakahira Kiichi K Choi Augustine Mk AM
JCI insight 20180503 9
In patients requiring ventilator support, mechanical ventilation (MV) may induce acute lung injury (ventilator-induced lung injury [VILI]). VILI is associated with substantial morbidity and mortality in mechanically ventilated patients with and without acute respiratory distress syndrome. At the cellular level, VILI induces necrotic cell death. However, the contribution of necroptosis, a programmed form of necrotic cell death regulated by receptor-interacting protein-3 kinase (RIPK3) and mixed-l ...[more]