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Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.


ABSTRACT: Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.

SUBMITTER: Wyche TP 

PROVIDER: S-EPMC6013059 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Wyche Thomas P TP   Ruzzini Antonio C AC   Beemelmanns Christine C   Kim Ki Hyun KH   Klassen Jonathan L JL   Cao Shugeng S   Poulsen Michael M   Bugni Tim S TS   Currie Cameron R CR   Clardy Jon J  

Organic letters 20170322 7


Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosyntheti  ...[more]

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