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ABSTRACT:
SUBMITTER: Rogers JM
PROVIDER: S-EPMC6205457 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Rogers Joseph M JM Passioura Toby T Suga Hiroaki H
Proceedings of the National Academy of Sciences of the United States of America 20181009 43
High-resolution structure-activity analysis of polypeptides requires amino acid structures that are not present in the universal genetic code. Examination of peptide and protein interactions with this resolution has been limited by the need to individually synthesize and test peptides containing nonproteinogenic amino acids. We describe a method to scan entire peptide sequences with multiple nonproteinogenic amino acids and, in parallel, determine the thermodynamics of binding to a partner prote ...[more]