Ontology highlight
ABSTRACT:
SUBMITTER: Dishon S
PROVIDER: S-EPMC6013495 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Dishon Shira S Schumacher Adi A Fanous Joseph J Talhami Alaa A Kassis Ibrahim I Karussis Dimitrios D Gilon Chaim C Hoffman Amnon A Nussbaum Gabriel G
Scientific reports 20180621 1
MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, the murine model of multiple sclerosis, and showed that the MyD88 BB-loop decoy peptide RDVLPGT ameliorates EAE. We now designed and screened a library of backbone cyclized peptides based on the linear BB loop peptide, to identify a metabolically stable inhibitor of MyD88 that retains the binding propert ...[more]