Ontology highlight
ABSTRACT:
SUBMITTER: Meyer RE
PROVIDER: S-EPMC6014172 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Meyer Régis E RE Brown Jamin J Beck Lindsay L Dawson Dean S DS
Molecular biology of the cell 20171213 4
In budding yeast meiosis, homologous chromosomes become linked by chiasmata and then move back and forth on the spindle until they are bioriented, with the kinetochores of the partners attached to microtubules from opposite spindle poles. Certain mutations in the conserved kinase, Mps1, result in catastrophic meiotic segregation errors but mild mitotic defects. We tested whether Dam1, a known substrate of Mps1, was necessary for its critical meiotic role. We found that kinetochore-microtubule at ...[more]