Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.
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ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC6014579 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.
Yang Lingjian L Roberts Darren D Takhar Mandeep M Erho Nicholas N Bibby Becky A S BAS Thiruthaneeswaran Niluja N Bhandari Vinayak V Cheng Wei-Chen WC Haider Syed S McCorry Amy M B AMB McArt Darragh D Jain Suneil S Alshalalfa Mohammed M Ross Ashley A Schaffer Edward E Den Robert B RB Jeffrey Karnes R R Klein Eric E Hoskin Peter J PJ Freedland Stephen J SJ Lamb Alastair D AD Neal David E DE Buffa Francesca M FM Bristow Robert G RG Boutros Paul C PC Davicioni Elai E Choudhury Ananya A West Catharine M L CML
EBioMedicine 20180423
<h4>Background</h4>Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.<h4>Method</h4>Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen ...[more]
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