Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC6014579 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
EBioMedicine 20180423
<h4>Background</h4>Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.<h4>Method</h4>Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen ...[more]