Development and validation of a hypoxia-related prognostic signature for breast cancer.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7377061 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Development and validation of a hypoxia-related prognostic signature for breast cancer.
Wang Jianxin J Wang Yuquan Y Xing Ping P Liu Qianqi Q Zhang Cong C Sui Yang Y Wu Changjun C
Oncology letters 20200616 2
Hypoxia, an important component of the tumor microenvironment, plays a crucial role in the occurrence and progression of cancer. However, to the best of our knowledge, a systematic analysis of a hypoxia-related prognostic signature for breast cancer is lacking and is urgently required. Therefore, in the present study, RNA-seq data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) and served as a discovery cohort. Cox proportional hazards regression analysis was perform ...[more]
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