Ontology highlight
ABSTRACT:
SUBMITTER: Han F
PROVIDER: S-EPMC6014586 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Han Fei F Liu Wen-Bin WB Shi Xiao-Yan XY Yang Jun-Tang JT Zhang Xi X Li Zhi-Ming ZM Jiang Xiao X Yin Li L Li Jian-Jun JJ Huang Chuan-Shu CS Cao Jia J Liu Jin-Yi JY
EBioMedicine 20180505
Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism of this metastasis remains unclear. Here, we investigate in lung cancer that SOX30 is sharply under-expressed in metastatic tumors compared with non-metastatic tumors, and suppresses plenty of metastasis related processes or pathways. SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo. Sox30 deficiency promotes lung metastasis in Sox30<sup>-/-</sup> mice and this uncontrollable lung-metasta ...[more]