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Transition Metal-Free 1,2-Carboboration of Unactivated Alkenes.

ABSTRACT: A method for transition metal-free 1,2-carboboration of unactivated alkenes with bis(catecholato)diboron as the boron source in combination with alkyl halides as the alkyl component is introduced. The three-component reaction proceeds via a radical pathway on a broad range of unactivated alkenes, and the 1,2-carboboration products serve as valuable synthetic building blocks. Density functional theory calculations provide insights into the mechanism.

SUBMITTER: Cheng Y

PROVIDER: S-EPMC6014685 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Transition Metal-Free 1,2-Carboboration of Unactivated Alkenes.

Cheng Ying Y Mück-Lichtenfeld Christian C Studer Armido A

Journal of the American Chemical Society 20180515 20

A method for transition metal-free 1,2-carboboration of unactivated alkenes with bis(catecholato)diboron as the boron source in combination with alkyl halides as the alkyl component is introduced. The three-component reaction proceeds via a radical pathway on a broad range of unactivated alkenes, and the 1,2-carboboration products serve as valuable synthetic building blocks. Density functional theory calculations provide insights into the mechanism. ...[more]

PMID: 29741375

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