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Metal-free Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System.

ABSTRACT: A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.

SUBMITTER: Liang S

PROVIDER: S-EPMC5937714 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Metal-free Regioselective Hydrochlorination of Unactivated Alkenes <i>via</i> a Combined Acid Catalytic System.

Liang Shengzong S Hammond Gerald B GB Xu Bo B

Green chemistry : an international journal and green chemistry resource : GC 20180102 3

A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorinatio ...[more]

PMID: 29750081

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