Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6014697 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wang Huaimin H Feng Zhaoqianqi Z Qin Yanan Y Wang Jiaqing J Xu Bing B
Angewandte Chemie (International ed. in English) 20180324 18
Herein, we report that assemblies of nucleopeptides selectively sequester ATP in complex conditions (for example, serum and cytosol). We developed assemblies of nucleopeptides that selectively sequester ATP over ADP. Counteracting enzymes interconvert ATP and ADP to modulate the nanostructures formed by the nucleopeptides and the nucleotides. The nucleopeptides, sequestering ATP effectively in cells, slow down efflux pumps in multidrug-resistant cancer cells, thus boosting the efficacy of doxoru ...[more]