Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6014699 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhou Yiming Y Castonguay Philip P Sidhom Eriene-Heidi EH Clark Abbe R AR Dvela-Levitt Moran M Kim Sookyung S Sieber Jonas J Wieder Nicolas N Jung Ji Yong JY Andreeva Svetlana S Reichardt Jana J Dubois Frank F Hoffmann Sigrid C SC Basgen John M JM Montesinos Mónica S MS Weins Astrid A Johnson Ashley C AC Lander Eric S ES Garrett Michael R MR Hopkins Corey R CR Greka Anna A
Science (New York, N.Y.) 20171201 6368
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocytes. Whether TRPC5 activity mediates FSGS onset and progression is ...[more]