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New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.

ABSTRACT: Four new spirostanol saponins, named pavitnosides A-D (1-4), with six known steroidal saponins 5-10 were isolated from the rhizomes of Paris vietnamensis. Their chemical structures were determined based on extensive spectroscopic studies and chemical methods. The aglycones of pavitnoside B and pavitnoside C were not reported in previous work. The cytotoxicity of all saponins was evaluated against human glioblastoma U87MG and U251 cell lines. The new spirostanol saponin 1 displayed weak anti-proliferative activity against U87MG cell line and the known saponins 8 and 9 exhibited significant cytotoxicity against the two tumor cell lines, with IC50 values of 2.16 to 3.14 ?M, but did not affect the growth of primary cultures of human astrocytes.

SUBMITTER: Liu Y

PROVIDER: S-EPMC6017139 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.

Liu Yang Y Wang Minchang M Liu Ke K Qiu Pengcheng P Zhang Shan S Lu Yunyang Y Tang Na N Tang Haifeng H

Molecules (Basel, Switzerland) 20180306 3

Four new spirostanol saponins, named pavitnosides A-D (1-4), with six known steroidal saponins 5-10 were isolated from the rhizomes of Paris vietnamensis. Their chemical structures were determined based on extensive spectroscopic studies and chemical methods. The aglycones of pavitnoside B and pavitnoside C were not reported in previous work. The cytotoxicity of all saponins was evaluated against human glioblastoma U87MG and U251 cell lines. The new spirostanol ...[more]

PMID: 29509694

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