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Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides.

ABSTRACT: Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively.

SUBMITTER: Yang BY

PROVIDER: S-EPMC6272963 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides.

Yang Bing-You BY Zhang Jing J Liu Yan Y Kuang Hai-Xue HX

Molecules (Basel, Switzerland) 20160817 8

Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values o ...[more]

PMID: 27548119

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