NMR-Fragment Based Virtual Screening: A Brief Overview.
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ABSTRACT:
SUBMITTER: Singh M
PROVIDER: S-EPMC6017141 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
NMR-Fragment Based Virtual Screening: A Brief Overview.
Singh Meenakshi M Tam Benjamin B Akabayov Barak B
Molecules (Basel, Switzerland) 20180125 2
Fragment-based drug discovery (FBDD) using NMR has become a central approach over the last twenty years for development of small molecule inhibitors against biological macromolecules, to control a variety of cellular processes. Yet, several considerations should be taken into account for obtaining a therapeutically relevant agent. In this review, we aim to list the considerations that make NMR fragment screening a successful process for yielding potent inhibitors. Factors that may govern the com ...[more]
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