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Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells.


ABSTRACT: Five previously undescribed triterpenoid saponins (1-5), along with eight known ones (6-13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC50 values of 18.21 and 15.56 ?M, respectively.

SUBMITTER: Wang XY 

PROVIDER: S-EPMC6017197 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells.

Wang Xiao-Yang XY   Gao Hui H   Xie Xiao-Jie XJ   Jurhiin Jirimubatu J   Zhang Mu-Zi-He MZ   Zhou Yan-Ping YP   Liu Rui R   Ning Meng M   Han Jin J   Tang Hai-Feng HF  

Molecules (Basel, Switzerland) 20180223 2


Five previously undescribed triterpenoid saponins (<b>1</b>-<b>5</b>), along with eight known ones (<b>6</b>-<b>13</b>), were isolated from the whole plants of <i>Anemone rivularis</i> var. <i>flore-minore</i>. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (<b>3</b> and <b>12</b>) were reported from the <i>Anemone</i> genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stell  ...[more]

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