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Pubescenosides E?K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity.


ABSTRACT: Seven new triterpenoid saponins (1?7), together with three known ones (8?10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells.

SUBMITTER: Qiao X 

PROVIDER: S-EPMC6100132 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Pubescenosides E⁻K, Seven New Triterpenoid Saponins from the Roots of <i>Ilex pubescens</i> and Their Anti-Inflammatory Activity.

Qiao Xiaoxu X   Ji Mengying M   Yao Yunda Y   Ma Leilei L   Wu Jinjun J   Liao Guochao G   Zhou Hua H   Liu Zhongqiu Z   Wu Peng P  

Molecules (Basel, Switzerland) 20180612 6


Seven new triterpenoid saponins (<b>1</b>⁻<b>7</b>), together with three known ones (<b>8</b>⁻<b>10</b>), were isolated from <i>Ilex pubescens</i>. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demon  ...[more]

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