Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC6017250 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wang Guizhen G Wang Xiyan X Sun Lin L Gao Yawen Y Niu Xiaodi X Wang Hongsu H
Molecules (Basel, Switzerland) 20180423 4
SortaseB (SrtB) plays a critical role in <i>Staphylococcus aureus</i> (<i>S. aureus</i>) infections. According to the reports in the literature, SrtB can anchor the IsdC to the cell wall to capture iron from the host to achieve a successful invasion. On the other hand, SrtB could also affect the adhesion of <i>S. aureus</i> to host cells based on previous studies. Here, we report about a novel SrtB inhibitor, coptisine, a natural compound that does not exhibit antibacterial activity but can inhi ...[more]