Ontology highlight
ABSTRACT:
SUBMITTER: Cruz JV
PROVIDER: S-EPMC6017386 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cruz Josiane V JV Neto Moysés F A MFA Silva Luciane B LB Silva Luciane B LB da S Ramos Ryan R da S Costa Josivan J Brasil Davi S B DSB Lobato Cleison C CC da Costa Glauber V GV Bittencourt José Adolfo H M JAHM da Silva Carlos H T P CHTP Leite Franco H A FHA Santos Cleydson B R CBR
Molecules (Basel, Switzerland) 20180218 2
The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2 signaling has been associated with various diseases, including sarcoidosis and inflammatory arthritis; the pharmacological inhibition of RIPK2 is an affinity strategy that demonstrates an increased expression of pro-inflammatory secretion activity. ...[more]