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Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum.

ABSTRACT: Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5-18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC₅₀ values of 30.23 ± 1.23 ?M and 19.36 ± 0.19 ?M, respectively.

SUBMITTER: Wu SY

PROVIDER: S-EPMC6017599 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum.

Wu Shou-Yuan SY Fu Yan-Hui YH Zhou Qi Q Bai Meng M Chen Guang-Ying GY Zhao Si-Yu SY Han Chang-Ri CR Song Xiao-Ping XP

Molecules (Basel, Switzerland) 20180222 2

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5-18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccha ...[more]

PMID: 29470386

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