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Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1).


ABSTRACT: Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 ?M.

SUBMITTER: Shi T 

PROVIDER: S-EPMC5484096 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1).

Shi Ting T   Qi Jun J   Shao Chang-Lun CL   Zhao Dong-Lin DL   Hou Xue-Mei XM   Wang Chang-Yun CY  

Marine drugs 20170525 6


Three new diphenyl ether derivatives-phomaethers A-C (<b>1</b>-<b>3</b>) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (<b>4</b>); and four isocoumarin derivatives, diaportinol (<b>5</b>), desmethyldiaportinol (<b>6</b>), citreoisocoumarinol (<b>7</b>), and citreoisocoumarin (<b>8</b>)-were isolated from a gorgonian-derived fungus <i>Phoma</i> sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigatio  ...[more]

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