Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC6017632 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
He Yuanzhi Y Chen Feixue F Sun Meijing M Gao Huifang H Guo Zewang Z Lin Hui H Chen Jiebo J Jin Wensong W Yang Yunlong Y Zhang Liaoyuan L Yuan Jun J
Molecules (Basel, Switzerland) 20180319 3
(3<i>S</i>)-Acetoin and (2<i>S</i>,3<i>S</i>)-2,3-butanediol are important platform chemicals widely applied in the asymmetric synthesis of valuable chiral chemicals. However, their production by fermentative methods is difficult to perform. This study aimed to develop a whole-cell biocatalysis strategy for the production of (3<i>S</i>)-acetoin and (2<i>S</i>,3<i>S</i>)-2,3-butanediol from <i>meso</i>-2,3-butanediol. First, <i>E. coli</i> co-expressing (2<i>R</i>,3<i>R</i>)-2,3-butanediol dehydr ...[more]