Ontology highlight
ABSTRACT:
SUBMITTER: Salomatina OV
PROVIDER: S-EPMC6017735 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Salomatina Oksana V OV Popadyuk Irina I II Zakharenko Alexandra L AL Zakharova Olga D OD Fadeev Dmitriy S DS Komarova Nina I NI Reynisson Jóhannes J Arabshahi H John HJ Chand Raina R Volcho Konstantin P KP Salakhutdinov Nariman F NF Lavrik Olga I OI
Molecules (Basel, Switzerland) 20180317 3
An Important task in the treatment of oncological and neurodegenerative diseases is the search for new inhibitors of DNA repair system enzymes. Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is one of the DNA repair system enzymes involved in the removal of DNA damages caused by topoisomerase I inhibitors. Thus, reducing the activity of Tdp1 can increase the effectiveness of currently used anticancer drugs. We describe here a new class of semisynthetic small molecule Tdp1 inhibitors based on the bile ac ...[more]