Ontology highlight
ABSTRACT:
SUBMITTER: Meine R
PROVIDER: S-EPMC6017736 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Meine Rosanna R Becker Walter W Falke Hannes H Preu Lutz L Loaëc Nadège N Meijer Laurent L Kunick Conrad C
Molecules (Basel, Switzerland) 20180124 2
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer's disease. The selective DYRK1A inhibitor 10-iodo-11<i>H</i>-indolo[3,2-<i>c</i>]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophilic molecule, suffers from poor water solubility, limiting its use as chemical probe in cellular assays and animal models. Based on the structure of KuFal194, 7-chloro-1<i>H</i>-indole-3 ...[more]