Ontology highlight
ABSTRACT:
SUBMITTER: Kirsch P
PROVIDER: S-EPMC6930586 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20191126 23
In this review, a general introduction to fragment-based drug design and the underlying concepts is given. General considerations and methodologies ranging from library selection/construction over biophysical screening and evaluation methods to in-depth hit qualification and subsequent optimization strategies are discussed. These principles can be generally applied to most classes of drug targets. The examples given for fragment growing, merging, and linking strategies at the end of the review a ...[more]