Ontology highlight
ABSTRACT:
SUBMITTER: Zarate SG
PROVIDER: S-EPMC6017855 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20180130 2
Resistance to aminoglycoside antibiotics has had a profound impact on clinical practice. Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of antibiotics to meet the challenge of resistance. The most prevalent source of clinically relevant resistance against these therapeutics is conferred by the enzymatic modification of the antibiotic. Therefore, a deeper knowledge of the aminoglycoside-modifying enzymes and their interactions with the antibiotics and s ...[more]