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Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

ABSTRACT: Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'-N-acetyltransferase (AAC(6')).

SUBMITTER: Vong K 

PROVIDER: S-EPMC5179255 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Vong Kenward K   Auclair Karine K  

MedChemComm 20120401 4

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'-<i>N</i>-acetyltransferase (AAC(6')). ...[more]

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