Ontology highlight
ABSTRACT:
SUBMITTER: Yamagishi T
PROVIDER: S-EPMC6018629 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Yamagishi Tatsuya T Yoshitake Kohei K Kamatani Daiki D Watanabe Kenji K Tsukano Hiroaki H Hishida Ryuichi R Takahashi Kuniyuki K Takahashi Sugata S Horii Arata A Yagi Takeshi T Shibuki Katsuei K
Scientific reports 20180625 1
Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by homophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mi ...[more]