Ontology highlight
ABSTRACT:
SUBMITTER: Denisov AY
PROVIDER: S-EPMC60200 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Denisov A Y AY Noronha A M AM Wilds C J CJ Trempe J F JF Pon R T RT Gehring K K Damha M J MJ
Nucleic acids research 20011101 21
Hybrids of RNA and arabinonucleic acid (ANA) as well as the 2'-fluoro-ANA analog (2'F-ANA) were recently shown to be substrates of the enzyme RNase H. Although RNase H binds to double-stranded RNA, no cleavage occurs with such duplexes. Therefore, knowledge of the structure of ANA/RNA hybrids may prove helpful in the design of future antisense oligonucleotide analogs. In this study, we have determined the NMR solution structures of ANA/RNA and DNA/RNA hairpin duplexes and compared them to the re ...[more]