Ontology highlight
ABSTRACT:
SUBMITTER: Ennifar E
PROVIDER: S-EPMC1950758 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20070713 9
Halogenation of bases is a widespread method used for solving crystal structures of nucleic acids. However, this modification may have important consequences on RNA folding and thus on the success of crystallization. We have used a combination of UV thermal melting, steady-state fluorescence, X-ray crystallography, and gel electrophoresis techniques to study the influence of uridine halogenation (bromination or iodination) on the RNA folding. The HIV-1 Dimerization Initiation Site is an RNA hair ...[more]