Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez MJ
PROVIDER: S-EPMC6020533 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rodriguez Maria J MJ Wangorsch Andrea A Gomez Francisca F Schülke Stefan S Torres Maria J MJ Vieths Stefan S Scheurer Stephan S Toda Masako M Mayorga Cristobalina C
Journal of immunology research 20180613
<h4>Background</h4>The use of hypoallergenic derivatives is considered beneficial to promote the safety and efficacy of allergen-specific immunotherapy. We aimed to assess the efficacy of reduced and alkylated (R/A) Pru p 3, a hypoallergenic folding variant of the major peach allergen, in subcutaneous immunotherapy (SCIT) using a murine model of peach allergy.<h4>Methods and results</h4>After sensitization with Pru p 3, BALB/c mice received SCIT with Pru p 3 or R/A Pru p 3 and were challenged wi ...[more]