Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC6020547 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wu Xuesong X Miao Jinmin J Li Yanrong Y Li Guigen G Ge Haibo H
Chemical science 20160426 8
Copper-promoted direct carbonylation of unactivated sp<sup>3</sup> C-H and aromatic sp<sup>2</sup> C-H bonds of amides was developed using nitromethane as a novel carbonyl source. The sp<sup>3</sup> C-H functionalization showed high site-selectivity by favoring the C-H bonds of α-methyl groups. The sp<sup>2</sup> C-H carbonylation featured high regioselectivity and good functional group compatibility. Kinetic isotope effect studies indicated that the sp<sup>3</sup> C-H bond breaking step is reve ...[more]