Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
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ABSTRACT:
SUBMITTER: Kinoshita M
PROVIDER: S-EPMC6020856 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
Kinoshita Manao M Hirayama Yuri Y Fujishita Kayoko K Shibata Keisuke K Shinozaki Youichi Y Shigetomi Eiji E Takeda Akiko A Le Ha Pham Ngoc HPN Hayashi Hideaki H Hiasa Miki M Moriyama Yoshinori Y Ikenaka Kazuhiro K Tanaka Kenji F KF Koizumi Schuichi S
EBioMedicine 20180608
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission of ATP. FLX increased ATP exocytosis via vesicular nucleotide transporter (VNUT). FLX-induced anti-depressive behavior was decreased in astrocyte-selective VNUT-knockout mice or when VNUT was deleted in mice ...[more]
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