Ontology highlight
ABSTRACT:
SUBMITTER: Petrossian K
PROVIDER: S-EPMC6021239 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Petrossian Karineh K Kanaya Noriko N Lo Chiao C Hsu Pei-Yin PY Nguyen Duc D Yang Lixin L Yang Lu L Warden Charles C Wu Xiwei X Pillai Raju R Bernal Lauren L Huang Chiun-Sheng CS Kruper Laura L Yuan Yuan Y Somlo George G Mortimer Joanne J Chen Shiuan S
Oncotarget 20180612 45
While ER has multiple biological effects, ER-cyclin D1-CDK4/6-RB is a critical pathway for the action of estrogen on the cell cycle, especially for breast cancers that rely on estrogen for growth. The latest and most efficient CDK4/6 inhibitors target the phosphorylation of retinoblastoma (RB) tumor suppressor gene; thus, altering levels of many cell cycle molecules. Estrogen receptor (ER)+/HER2- breast cancers have shown great progression free survival when CDK4/6 inhibitors are combined with e ...[more]