Ontology highlight
ABSTRACT:
SUBMITTER: Degosserie J
PROVIDER: S-EPMC6022243 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Degosserie Jonathan J Heymans Charlotte C Spourquet Catherine C Halbout Mathias M D'Auria Ludovic L Van Der Smissen Patrick P Vertommen Didier D Courtoy Pierre J PJ Tyteca Donatienne D Pierreux Christophe E CE
Journal of extracellular vesicles 20180628 1
Organogenesis is a complex and dynamic process requiring reciprocal communication between different cell types. In the thyroid, thyrocyte progenitors secrete the angiocrine factor, VEGFA, to recruit endothelial cells. In return, endothelial cells promote thyrocyte organisation into spherical follicular structures, which are responsible for thyroid hormone synthesis and storage. Medium conditioned by endothelial progenitor cells (EPCs) can promote follicle formation and lumen expansion (i.e. foll ...[more]